The Science

The Science Behind
NMN & NAD+Researchers follow NMN as a precursor the body can use on the way to NAD+.Research on this page is not a product promise.

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In one 60-day trial, blood biological age rose on placebo (39.8 → 45.4 years) and held steady with 600 mg of NMN a day (45.2 → 44.1 years, not a significant change). Yi et al., GeroScience 2023.

TWO AGES, ONE YOU

Imagine your birthday age, and the age your body lives.

Two ages: the one on your birthday and the one your body lives. One is counted in candles. The other is estimated from your biology.

CHRONOLOGICAL AGE · THE RINGBIOLOGICAL AGE · THE ORB

PLACEBO · 60 DAYS

Sixty days pass. On placebo, biological age rose.

Biological age

Started at 39.8 years · Rose

CHRONOLOGICAL AGE · THE RINGBIOLOGICAL AGE · THE ORB

NMN 600 MG/DAY · 60 DAYS

Sixty days at 600 mg of NMN a day. Biological age held steady.

Biological age

Started at 45.2 years · Held steady (no significant change)

CHRONOLOGICAL AGE · THE RINGBIOLOGICAL AGE · THE ORB

THE STUDY

In one 60-day trial, biological age rose on placebo. At 600 mg of NMN a day, it held steady.

Placebo: 39.8 → 45.4 years · Rose
NMN 600 mg/day: 45.2 → 44.1 years · Held steady

Blood biological age estimated from 19 blood markers (Aging.Ai 3.0), a secondary outcome. 80 healthy adults aged 40–65, 20 per group (placebo, 300, 600 or 900 mg NMN daily); 600 mg group shown. One trial, funded by the ingredient's manufacturers. Yi et al., GeroScience 2023.

Study

CHRONOLOGICAL AGE · THE RINGBIOLOGICAL AGE · THE ORB

TWO AGES, ONE YOU

Imagine your birthday age, and the age your body lives.

Two ages: the one on your birthday and the one your body lives. One is counted in candles. The other is estimated from your biology.

THE STUDY

In one 60-day trial, biological age rose on placebo. At 600 mg of NMN a day, it held steady.

Placebo: 39.8 → 45.4 years · Rose
NMN 600 mg/day: 45.2 → 44.1 years · Held steady

Study

CHRONOLOGICAL AGE · THE RINGBIOLOGICAL AGE · THE ORB

The NAD+ pathway

From NMN to NAD+
to the mitochondria

Three steps on one hairline. Each model is built from published structures and drawn to the same scale family.

01
NMN
Nicotinamide mononucleotide
A nucleotide that cells convert into NAD+.
02
NAD+
Nicotinamide adenine dinucleotide
A coenzyme found in every living cell.
03
Mitochondria
The cell's energy organelles
Where NAD+ takes part in cellular energy metabolism.

Longevity pathways

The Anera Longevity Map

NAD+ sits at the center. One line runs through the chemistry researchers study.

01 In the body

NAD+ with age

02 Precursor

NMN

03 Coenzyme

NAD+

04 In the cell

Mitochondria

05 Proteins

Sirtuins

ResveratrolStill being studied

06 In the body

Oxidative stress

Research on NAD+ and NMN is not a product promise.

Research notes

What the studies look at

Researchers study NMN as a precursor the body can convert into NAD+. Studies of human skin tissue and in animals have found NAD+ levels tend to be lower later in life.

Both ingredients come up in sirtuin research. Sirtuins are proteins that depend on NAD+, first shown in yeast, and NMN is studied in that same body of work. Early laboratory studies reported that resveratrol could activate sirtuins; later research has questioned how this works, and it is still being studied. This shared research context is why scientists often look at them together. It does not describe what Anera products do in the body.

Research, not a product claim.

References

01NMN
Mills KF, Yoshida S, Stein LR, et al. Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metab. 2016;24(6):795-806.
doi:10.1016/j.cmet.2016.09.013 PMID 28068222
02NAD+
Yoshino J, Baur JA, Imai S. NAD+ intermediates: the biology and therapeutic potential of NMN and NR. Cell Metab. 2018;27(3):513-528.
doi:10.1016/j.cmet.2017.11.002 PMID 29249689
03Oxidative stress
Massudi H, Grant R, Braidy N, et al. Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS One. 2012;7(7):e42357.
doi:10.1371/journal.pone.0042357 PMID 22848760
04Resveratrol
Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006;5(6):493-506.
doi:10.1038/nrd2060 PMID 16732220
05Sirtuins
Imai S, Armstrong CM, Kaeberlein M, Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature. 2000;403(6771):795-800.
doi:10.1038/35001622 PMID 10693811
06Yeast
Howitz KT, Bitterman KJ, Cohen HY, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003;425(6954):191-196.
doi:10.1038/nature01960 PMID 12939617
07Clinical trial
Yi L, Maier AB, Tao R, et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. GeroScience. 2023;45(1):29-43.
doi:10.1007/s11357-022-00705-1 PMID 36482258